Separated from her incarcerated husband Bill (Hinds), Trish (Janney) is about to be married again. Bill is a pedophile, so Trish couldn't be more excited to have Harvey (Lerner), a "normal" father figure for her two sons. But when Bill is released from prison and the boys finally meet their future stepdad, the family is forced to decide whether to forgive or to forget. Trish's sister, the virginal, angelic Joy (Henderson), is also haunted by ghosts of lovers past. On leave from her degenerate husband, Allen (Williams), and her job at a New Jersey correctional facility, Joy unwittingly leaves behind a trail of shame and exposed secrets wherever she goes. In one of the film's most stylized sequences, the image of Joy walking the dark streets of Miami in her nightgown maintains her innocence against a backdrop of self-affliction and desire.

Kym is released from rehab for a few days so she can go home to attend her sister Rachel's wedding. The home environment is always challenging for a recovering addict, no less so when the visit if only for a few days. While the sisters feel genuine affection for one another, there is tension in their relationship. Rachel feels that her father dotes on Kym far too much and Kym is upset to learn that Rachel has selected a friend to be her maid of honor. Their father is genuinely concerned about Kym's well-being but doesn't see the stress the relationship is causing. Both women also have to deal with their selfish mother who is clearly more concerned with her own well-being ahead of that of her children. Underlying the family's dynamic is a tragedy that occurred many years previously and for which Kym is held by some to be responsible.